phenobarbital boosts toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. CYP3A4 inducers may possibly increase the metabolism of ifosfamide to its active alkylating metabolites.Hypnotic doses of barbiturates will not seem to impair uterine action noticeably for the duration of labor. Total ane